About the position We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro and ex vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.

Responsibilities

• Conduct hands-on laboratory experiments following established protocols to generate CAR T cells.
• Perform and optimize cytotoxicity and flow cytometry assays.
• Perform and validate ELISpot, ELISA, Luminex, or other assays as needed.
• Maintain and expand, bank, and manage various cell lines.
• Actively contribute to process improvements and the implementation of new technologies.
• Perform lab associated tasks in accordance with Cabaletta Bio lab safety policies and SOPs.
• Ensure proper maintenance and cleanliness of laboratory equipment and workspaces.
• Maintain accurate and well-organized records and electronic laboratory notebook.
• Analyze experimental data using basic statistical methods and software tools to generate meaningful insights.
• Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions.
• Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0-2 years, or Master's degree with a minimum of 5 years, or Bachelor’s degree with minimum of 10 years of experience.
• Hands-on experience with cell culture and basic molecular biology techniques. Extensive hands-on experience with primary immune cell-based assays advantageous.
• General lab skills, including aseptic techniques and human tissue handling required.
• Must have prior experience and be highly skilled at mammalian cell culture (aseptic techniques).
• Experience in primary cell husbandry, cytotoxicity assays, and flow cytometry.
• Must be highly organized and able to work independently.
• A high level of flexibility to support various other activities and the ability to learn new techniques outside of existing field of expertise.
• Strong team orientation and passion for continuous self-development.
• Strong organizational skills, attention to detail, and the ability to follow protocols accurately.
• Effective written and verbal communication skills to share experimental findings and collaborate with team members.

Nice-to-haves

• Experience working in a research or industry setting related to immunology, cell therapy, or gene editing.
• Experience in industry or in a startup industrial setting.
• Solid understanding of CAR T cell therapy, immune cell biology, and cellular immunotherapy.
• Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.

Benefits

• Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.