Amgen seeks a Principal Scientist in Computational Biology & Translational AI focused on developing AI-enabled analytical systems connecting preclinical and clinical data across oncology programs. Key Responsibilities: - Lead pan-asset forward and reverse translational analyses integrating multiple data types to generate mechanistic insights - Design generative and agentic AI systems for hypothesis generation and evidence synthesis - Develop multi-agent workflows integrating omics, imaging, pathology, and clinical data - Build reproducible translational analysis pipelines with AI integration - Partner with biology, pathology, and clinical teams to contextualize translational signals - Communicate findings to clinical and scientific stakeholders Minimum Qualifications (one of): - PhD/PharmD/MD + 2 years computational biology experience - Master's + 5 years experience - Bachelor's + 7 years experience Preferred Qualifications: - PhD in bioinformatics, statistics, computer science, or related field with biology foundation - Demonstrated expertise in translational science linking molecular mechanisms to clinical outcomes - Hands-on experience with generative or agentic AI systems - Multi-modal data integration experience - Strong programming in R and/or Python - Knowledge of clinical biomarker platforms Salary: $167,413 - $226,501 annually