About the Role

Our client, a leader in pharmaceutical research and development, is actively recruiting for a Senior Computational Chemist to join their innovative, remote-first R&D division. This position is crucial for advancing drug discovery efforts through the application of sophisticated computational methods. You will play a key role in designing and executing in silico studies, developing predictive models, and contributing to the identification of novel therapeutic candidates. The ideal candidate will possess a strong background in computational chemistry, cheminformatics, and molecular modeling, with a passion for leveraging computational tools to solve complex biological and chemical problems. This role offers the unique advantage of contributing to impactful research from a fully remote setting, collaborating with a highly skilled international team.

Key Responsibilities

Develop and apply computational chemistry techniques, including molecular modeling, docking, virtual screening, and QM/MM calculations, to drug discovery projects. Design and execute in silico experiments to predict compound properties, binding affinities, and pharmacokinetic profiles. Build and refine quantitative structure-activity relationship (QSAR) models and other predictive cheminformatics tools. Collaborate closely with medicinal chemists, biologists, and pharmacologists to guide experimental design and interpret results. Analyze large datasets generated from computational studies and experimental assays. Stay current with the latest advancements in computational chemistry software, algorithms, and methodologies. Document research activities, present findings at scientific meetings, and contribute to publications and patent applications. Contribute to the strategic planning of computational chemistry initiatives within the R&D organization. Mentor junior computational chemists and provide technical guidance.

Requirements

Ph.D. in Computational Chemistry, Cheminformatics, Physical Chemistry, or a related field. Minimum of 6 years of post-doctoral or industry experience in computational chemistry, with a focus on drug discovery. Expertise in molecular modeling software (e.g., Schrödinger, MOE, OpenEye) and a strong understanding of theoretical chemistry principles. Proficiency in scripting languages such as Python for data analysis and workflow automation. Experience with cheminformatics databases and tools. Demonstrated ability to manage multiple projects simultaneously and deliver results within project timelines. Excellent analytical and problem-solving skills. Strong written and verbal communication skills, with the ability to present complex scientific information clearly. Proven ability to work independently and productively in a remote environment.

Benefits

Our client offers a competitive salary and a comprehensive benefits package designed to support a remote workforce. This includes excellent health, dental, and vision insurance, a robust 401(k) plan with company match, and generous paid time off. We provide resources for home office setup and continuous professional development, including access to online training and virtual conferences. The fully remote nature of this position offers unparalleled flexibility and work-life balance. You will be part of a forward-thinking R&D team making significant contributions to human health, collaborating seamlessly from anywhere, even though our primary operations are centered in Richmond, Virginia .