cFocus Software seeks a Information Systems Security Officer (ISSO) to join our program supporting the National Institutes of Health (NIH). This position is fully remote. This position requires a Public Trust or the ability to obtain a public trust clearance. Qualifications:Public Trust Clearance B.S. Computer Science, Information Technology, or a related field 5+ years of experience supporting Federal information security programs. Experience supporting Federal Assessment and Authorization (A&A) efforts. Experience implementing NIST Risk Management Framework (RMF) controls. Active CISSP, CAP, Security+, CISM, GSLC, or GSEC Duties:Serve as the primary Information System Security Officer (ISSO) for assigned NIH information systems. Implement and maintain the NIST Risk Management Framework (RMF) throughout the system development lifecycle. Support Assessment and Authorization (A&A) activities for Low and Moderate FISMA systems. Develop, maintain, and update System Security Plans (SSPs), Security Assessment Plans (SAPs), Security Assessment Reports (SARs), Plans of Action and Milestones (POA&Ms), security categorization documentation, and supporting authorization artifacts. Coordinate with System Owners to implement and maintain NIST SP 800-53 Rev. 5 security controls. Perform continuous monitoring activities to verify ongoing compliance with Federal cybersecurity requirements. Monitor security vulnerabilities and coordinate remediation efforts with system administrators and technical teams. Track, update, and report POA&M items through successful remediation and closure. Review vulnerability scan results and ensure corrective actions are completed within required timelines. Support annual FISMA assessments and internal/external cybersecurity audits. Assist in developing security risk assessments and documenting residual risk. Coordinate security control assessments with Security Control Assessors (SCAs). Support the preparation of authorization packages for Authorizing Officials (AOs). Review proposed system changes for cybersecurity impacts and ensure appropriate security documentation is updated. Maintain accurate cybersecurity documentation throughout the authorization lifecycle. Assist with Risk Mitigation Waiver documentation and implementation of compensating security controls. Provide cybersecurity guidance to System Owners regarding Federal information security requirements. Participate in security architecture reviews and system design discussions. Develop cybersecurity status reports, metrics, and compliance documentation for management. Ensure compliance with FISMA, OMB guidance, HHS cybersecurity policy, NIH security requirements, and NIST standards. Participate in cybersecurity incident response activities and coordinate with enterprise cybersecurity teams when required.