Osteal Therapeutics is a Dallas-based, privately held biotechnology company redefining the standard of care for life-altering orthopedic infections. At the heart of our pipeline is NEXCHANGE™ KIT, a first-of-its-kind FDA-designated Breakthrough Therapy for periprosthetic joint infection (PJI) — a devastating condition that strikes 50,000 Americans each year. Once diagnosed, PJI patients face a dramatically diminished quality of life, the threat of amputation, and a five-year survival rate worse than that of melanoma. Today, they must navigate a grueling, month-long treatment journey with no FDA-approved therapy and uncertain outcomes. NEXCHANGE KIT fundamentally changes the patient journey by reducing the treatment time from months to just seven days. It replaces uncertainty with a defined protocol, enabled by the safe delivery of broad-spectrum antibiotics directly to the site of infection at sustained concentrations up to 1,000 times higher than standard systemic therapies. With NEXCHANGE KIT, Osteal is not simply launching a product. We are creating an entirely new therapeutic category. Powered by $137M in funding to date and a distinguished investor base that includes strategic partners Johnson & Johnson and Zimmer Biomet, we are advancing toward FDA approval and building the organization that will bring this therapy to patients in dire need. We are looking for bold, relentless professionals who thrive in a “builder” environment. If you are driven by the opportunity to do work that genuinely matters — to be part of a cohesive and capable team striving to deliver the first on-label PJI treatment that promises to transform outcomes for tens of thousands of patients — there has never been a better moment to join Osteal Therapeutics. \n

Summary

The Area Vice-President, Sales is a first-line sales leader responsible for launching the NEXCHANGE KIT, Osteal’s lead investigational therapy for periprosthetic joint infection, which has received FDA Breakthrough Therapy, Fast Track, Orphan Drug, and Qualified Infectious Disease designations. This role builds the regional Account Manager team, owns launch execution, surgeon adoption, and translates national strategy into account-level plans. The AVP partners across Marketing, Market Access, Medical Affairs and Training to deliver an aligned go-to-market strategy and serves as the voice of the field in shaping commercial strategy. The role demands an entrepreneurial builder with prior launch leadership, deep credibility in orthopedics and the operating room, and the resilience to drive results in a fast-moving, pre-commercial environment. As Osteal builds the commercial organization, this leader will have the opportunity to shape the future field structure, including recruiting and developing District Managers, and growing into broader second-line leadership responsibilities over time.

Responsibilities

Responsibilities of the position include but are not limited to the following. Other duties may be assigned. Recruit, develop, and lead a high-performing team of Account Managers. Provide field-based coaching through joint calls and in-hospital support. Own regional sales forecasting, pipeline management, and performance reporting: conduct ongoing performance management and provide input on compensation plan design and quota setting. Translate national strategy into actionable regional, territory and account level plans aligned to launch objectives. Drive regional launch execution including site activation, surgeon adoption, and achievement of quarterly revenue and unit goals. Identify, develop, and cultivate regional KOLs and centers of excellence in orthopedic infection management. Partner cross-functionally with Marketing, Market Access, Medical Affairs, Training and Operations to drive aligned execution. Serve as the voice of the field, bringing insights that inform strategy and decision-making. Ensure team adherence to all applicable laws, regulations, and company policies.

Qualifications

Bachelor’s degree or equivalent required, advanced degree preferred. 8+ years of commercial experience selling medical devices, biologics, or specialty pharmaceuticals into hospitals and surgical settings, with documented quota attainment. Minimum 3 years of first-line sales leadership experience directly managing W-2 sales representatives in a direct sales model. Experience limited to managing independent distributors, 1099 reps, or third-party channel partners does not satisfy this requirement. Proven launch leadership experience as a first-line manager during a new product launch (pre-launch readiness through the first 24 months of commercialization), preferably within a pre-commercial or early commercial-stage company. Orthopedic and operating room selling experience strongly preferred, including established relationships with orthopedic surgeons, infectious disease specialists, and hospital decision-makers (e.g., Pharmacy & Therapeutics & Value Analysis Committees). Exceptional ability to translate sophisticated scientific data into actionable clinical insights that build trust with surgeons, pharmacists, and infectious disease specialists. Ability to manage multiple priorities and thrive in a fast-paced, evolving organization.

Preferred Qualifications

Entrepreneurial builder mindset with a bias toward action. Strong cross-functional collaborator and partner. Bring strong analytical rigor, capable of developing, operationalizing, and adapting complex regional, territory and account level plans in dynamic environments. Demonstrated success in specialty product launches, preferably within rare disease, orthopedics, infectious disease, or other complex, hospital-based therapeutic areas. High degree of agility and resilience, with the ability to operate effectively in ambiguity, reprioritize rapidly, and drive progress in a fast-paced, pre-commercial or startup environment. Location US based candidates only, must reside East of the Mississippi River Up to 75% of travel required \n